UTHSC gets $2.5M NIH grant for nicotine research

Categories:
· Health/Science
International:
· USA
Source:http://www.commercialappeal.com/,2009-11-01
A $2.5 million grant could help University of Tennessee Health Science Center researchers find out if some adolescents are more genetically prone to nicotine use than others.

A team of six researchers in two departments won the Grand Opportunity Grant from the National Institutes of Health. The grant funds came from the American Reinvestment and Recovery Act and will run through 2011.

Dr. Burt M. Sharp is the lead investigator on the project, one of only 75 nationwide to receive funds through the program. Sharp said 2,600 research teams submitted projects for the grant program.

"We know not all 13-year-olds have the same likelihood to become dependent on cigarettes after exposure," Sharp said. "There's a good basis for us to do this study from a public health need, but we also know the genetics are there and that we have the tools to do it now in modern neurobiology."

Sharp is joined in the project with his UTHSC Department of Pharmacology colleagues Shannon Matta and Hao Chen. They will work with UTHSC neurogenetic researchers Yan Cui, William Taylor and Robert Williams.

The grant will enable the team to hire seven employees, mostly postdoctorate researchers, and buy equipment to speed the research along. The team will use animal models to prove that genes inside the brain's neurons can serve as predictors to nicotine vulnerability.

Sharp said the grant could be the "new road" down a decades-long path to a drug that, perhaps, could help those who are genetically disposed to nicotine to kick the habit.

The GO Grants were awarded to projects that could make a big push toward new fields of scientific inquiry, according to the NIH. They were awarded, too, based on their shovel-readiness.

"We will support large biomedical and biobehavioral research endeavors that will benefit from a significant two-year jump-start in funds and are ready for immediate implementation," said acting NIH director Dr. Raynard S. Kington.

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